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Association of annexin A2 with cancer development (Review)

Xiao-Heng Xu1, Wei Pan2, Li-Hua Kang1

  • 1Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, P.R. China.

Oncology Reports
|March 12, 2015
PubMed

Insights

Annexin A2 (ANXA2) is a protein involved in various cellular processes. This review explores its role in cancer progression, highlighting its potential as a therapeutic target.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Annexin A2 (ANXA2) is a calcium-dependent phospholipid-binding protein found in various cellular compartments.
  • ANXA2 is a pleiotropic protein influencing numerous molecular and cellular functions.
  • Aberrant ANXA2 expression is associated with diseases like cancer, autoimmune disorders, and inflammation.

Purpose of the Study:

  • To systematically review the multifaceted roles of Annexin A2 in tumor progression.
  • To elucidate the mechanisms underlying ANXA2's involvement in cancer development.
  • To identify ANXA2 as a potential therapeutic target for cancer treatment.

Main Methods:

  • Systematic literature review of studies on Annexin A2 and cancer.
  • Analysis of ANXA2's effects on tumor cell adhesion, proliferation, apoptosis, invasion, and metastasis.
  • Examination of ANXA2's role in tumor neovascularization.

Main Results:

  • ANXA2 is aberrantly expressed across a wide spectrum of cancers.
  • ANXA2 significantly impacts key hallmarks of cancer, including proliferation, invasion, and metastasis.
  • ANXA2 influences tumor angiogenesis through various mechanisms.

Conclusions:

  • Understanding the complex mechanisms of ANXA2 in cancer is crucial for developing effective therapies.
  • ANXA2 represents a promising molecular target for novel cancer treatment strategies.
  • Further research into ANXA2's functions may unlock new avenues for cancer therapy.

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