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Neurotrophic effect of cholecystokinin on ventral spinal cord in culture
Y Iwasaki1, M Kinoshita, K Ikeda
1Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Japan.
Neurological Research
|December 1, 1989
Abstract:
Studies of the effect of cholecystokinin on organotypic cultures of rat ventral spinal cord revealed that concentrations of 10(-4) to 10(-14) M exert a marked growth-stimulating effect. In the presence of cholecystokinin, the neuritic extension of the ventral spinal cord exceeds control values 3.5-6.5 times. The growth zone of spinal cord explants increases in cholecystokinin-treated cultures. The possible mechanism of the trophic effect of cholecystokinin on the ventral spinal cord is discussed briefly.