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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
A photoinduced cyclization cascade-total synthesis of (-)-leuconoxine
Magnus Pfaffenbach1, Tanja Gaich
1Institute of Organic Chemistry, Leibniz University of Hannover, Schneiderberg 1b, 30167 Hannover (Germany).
Abstract:
A protecting-group-free and enantioselective total synthesis of the monoterpenoid indole alkaloid (-)-leuconoxine was accomplished. The key step comprises a novel photoinduced domino macrocyclization/transannular cyclization involving the Witkop cyclization, for which additional mechanistic evidence is provided. This process furnishes a diaza[5.5.6.6]fenestrane skeleton, which is a hitherto unprecedented structure element.
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