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Updated: Apr 16, 2026

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
Published on: May 23, 2025
[Sarcoma of the hand and wrist]
H U Steinau1, F Farzaliyev1, I Stricker2
1Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Sektion Sarkomchirurgie, Westdeutsches Tumorzentrum CCC, Universitätsklinikum Essen, Universität Duisburg-Essen.
Abstract:
Sarcomas of the hand and wrist are rare malignancies, which should be referred to high-volume comprehensive cancer centres providing multidisciplinary treatment options. The tumour board should propose patient-oriented oncological pathways as well as sophisticated hand and plastic reconstructive procedures. In Addition, isolated limb perfusion with TNF-alpha and melphalan is likely to lead to preoperative tumour shrinkage allowing for R0 resection in sano. Our clinical results in long-term survivors demonstrate reduced amputation rates and salvage of basic hand function when a risk-adapted treatment rationale is applied.
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