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Effects of SCH 23390 on thyrotropin-releasing hormone-induced behaviour in rabbits
P Popoli1, M G Caporali, A Scotti de Carolis
1Department of Pharmacology, Istituto Superiore di Sanitù, Rome, Italy.
European Journal of Pharmacology
|December 7, 1989
Abstract:
The influence of the dopamine D-1 receptor antagonist, SCH 23390, on thyrotropin-releasing hormone (TRH)-induced behaviour was assessed in adult male rabbits. SCH 23390 prevented the effects of TRH (100 micrograms i.c.v.), starting at a very low dose (0.01 mg/kg i.v.). This finding seems to indicate that dopamine D-1 receptors are involved in TRH-induced behaviour.