Related Experiment Video

Updated: Apr 16, 2026

Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
03:38

Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models

Published on: June 20, 2025

1.2K

Changes in Pulmonary Function and Controlled Ventilation-High Resolution CT of Chest After Antibiotic Therapy in

Shahid I Sheikh1, Frederick R Long, Robert Flucke

  • 1Departments of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA, Shahid.Sheikh@nationwidechildrens.org.

Lung
|March 13, 2015
PubMed

Insights

Infant pulmonary function tests (IPFT) and controlled ventilation-high resolution computed tomography (CV-HRCT) objectively measure lung disease improvement in infants with cystic fibrosis (CF) after antibiotic treatment. These methods confirm positive changes following intravenous antibiotic therapy in early CF lung disease.

Area of Science:

  • Pediatric Pulmonology
  • Medical Imaging
  • Respiratory Medicine

Background:

  • Infants with cystic fibrosis (CF) experience early, progressive lung disease, often asymptomatic.
  • Infant pulmonary function tests (IPFT) and controlled ventilation-high resolution computed tomography (CV-HRCT) can detect early, asymptomatic lung disease in infants.
  • The ability of these objective measures to track changes after interventions is not well-established.

Purpose of the Study:

  • To evaluate the usefulness of IPFT and CV-HRCT in detecting lung disease changes in infants with early CF.
  • To assess the impact of intravenous (IV) antibiotic therapy on lung disease in infants with CF using objective measures.

Main Methods:

  • A retrospective comparison of IPFT and CV-HRCT data from infants with early CF-related lung disease before and after 2 weeks of IV antibiotics.
  • CV-HRCT images were analyzed using the modified Brody scoring system.
  • Data from 21 infants, with a mean age of 85.2 ± 47.6 weeks, were analyzed.

Main Results:

  • Significant improvements were observed in IPFT measures, including % predicted FEV(0.5) (+13.5%), %FEF(25-75) (+30.2%), %RV/TLC (-11.2%), and %FRC/TLC (-4.5%).
  • Total Brody scores on CV-HRCT significantly improved from a median of 10 to 5.
  • Specific CV-HRCT scores for airway wall thickening, air trapping, and parenchymal opacities also showed significant improvement.

Conclusions:

  • IPFT and CV-HRCT serve as objective tools to measure lung disease improvement in infants with CF.
  • These methods demonstrate efficacy in assessing treatment response to antibiotics in pediatric CF patients.
  • The findings support the use of IPFT and CV-HRCT for monitoring therapeutic interventions in early CF lung disease.
Abstract

More Related Videos

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

9.7K
Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging10:44

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

1.4K

Related Concept Videos

Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
647
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
1.1K
Chest Physiotherapy01:24

Chest Physiotherapy

Chest Physiotherapy (CPT) is a therapeutic technique used in respiratory care to improve ventilation, clear bronchial secretions, and enhance the efficiency of respiratory muscles. This therapy includes three primary procedures: postural drainage, percussion, and vibration. It can be performed on spontaneously breathing patients and those who are intubated and mechanically ventilated.
Purpose
CPT is primarily used for patients with excessive bronchial secretions who have difficulty clearing...
2.8K
Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
1.1K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.4K
Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
941