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Intracranial Hypertension in Children: Etiologies, Clinical Features, and Outcome
Amira Masri1, Amani Jaafar2, Rasha Noman3
1Faculty of Medicine, Division of Child Neurology, Department of Pediatrics, University of Jordan, Amman, Jordan masriamira69@hotmail.com.
Insights
Idiopathic intracranial hypertension in children is often linked to vitamin D deficiency. Most children recover within a year, but some may develop vision issues, especially those with prior eye conditions.
Area of Science:
- Pediatric Neurology
- Ophthalmology
- Endocrinology
Background:
- Idiopathic intracranial hypertension (IIH) is a neurological condition affecting children.
- Understanding the causes and outcomes in pediatric IIH is crucial for effective management.
Purpose of the Study:
- To describe the clinical features, potential causes, and outcomes of pediatric IIH.
- To identify common comorbidities and long-term effects in children diagnosed with IIH.
Main Methods:
- Retrospective analysis of 19 pediatric patients diagnosed with IIH.
- Review of clinical presentations, identified causes, comorbidities, and treatment outcomes.
Main Results:
- The mean age of onset was 6 years; 90% were under 11.
- Vitamin D deficiency was the most common identified cause (26.3%).
- Cerebrospinal fluid pressure normalized in most patients within 6 weeks to 1 year; 30.7% developed optic atrophy.
Conclusions:
- Vitamin D deficiency is a significant potential cause of IIH in children.
- While most children recover, long-term ophthalmological monitoring is essential due to the risk of optic atrophy, particularly in those with pre-existing ocular conditions.
Abstract:
This retrospective study aimed to describe the clinical presentations, possible causes, and outcomes of children with idiopathic intracranial hypertension who presented to the authors' clinic. The mean age at onset of symptoms in the authors' cohort of 19 children was 6 years (range: 7 months to 12 years). Most patients (90%) were under 11 years old and (84.2%) symptomatic. The probable cause was identified in 7/19 (37.0%) patients. The most common cause was vitamin D deficiency (26.3%). Other associated probably coincidental comorbidities included sinusitis (5/19, 26.3%), hypophosphatasia (1/19), Pyle disease (1/19), and measles vaccine (1/19). Apart from 2 patients who required lumboperitoneal shunt, the cerebrospinal fluid pressure returned to normal in all patients within a period of 6 weeks to 1 year (average, 5 months). Of those who followed up with the authors' ophthalmologist, 30.7% developed optic atrophy or pallor; 75% of these patients had previous ocular comorbidities.
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