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Updated: Apr 16, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
Unsaturated fatty acid-induced non-canonical autophagy: unusual? Or unappreciated?
1E.L. Wehner-Welch Laboratory, Department of Molecular & Cellular Medicine, Texas A&M University Health Science Center, College Station, TX, USA.
Abstract:
The breakdown of cellular components via autophagy is crucial for cellular homeostasis.In this issue of The EMBO Journal,Niso-Santano et al (2015) report the important observation that feeding cells with saturated or unsaturated fatty acids triggers mechanistically distinct autophagic responses. Feeding cells saturated fatty acid induced the canonical, BECN1/PI3K dependent autophagy pathway. Conversely,the unsaturated fatty acid oleate triggered autophagic responses that were independent of the BECN1/PI3K complex, but that required a functional Golgi system.
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