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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

MicroRNAs

MicroRNAs

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Related Experiment Video

Updated: Apr 16, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

miR2GO: comparative functional analysis for microRNAs.

Anindya Bhattacharya¹, Yan Cui¹

¹Department of Microbiology, Immunology and Biochemistry and Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Bioinformatics (Oxford, England)

|March 13, 2015

Summary

This summary is machine-generated.

miR2GO is a new web platform for analyzing human microRNA (miRNA) functions. It assesses mutation effects and compares miRNA functions using Gene Ontology annotations.

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Last Updated: Apr 16, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

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Area of Science:

Bioinformatics
Genomics
Molecular Biology

Background:

MicroRNAs (miRNAs) play crucial roles in gene regulation.
Understanding miRNA function and the impact of mutations is vital in molecular biology.
Comparative analysis of miRNA functions can reveal insights into biological pathways.

Purpose of the Study:

To introduce miR2GO, a web-based platform for comparative analysis of human miRNA functions.
To provide tools for assessing the functional impact of miRNA mutations.
To enable comparison of functions between different miRNAs.

Main Methods:

miR2GO includes two programs: miRmut2GO and miRpair2GO.
miRmut2GO uses a knowledge-based method comparing Gene Ontology (GO) annotations of target genes for wild-type and mutated miRNAs.
miRpair2GO compares miRNA functions based on enriched GO annotations of their target gene sets.

Main Results:

The platform facilitates the assessment of functional effects of genetic and somatic mutations in miRNA seed regions.
It enables semantic comparison of enriched GO annotations to understand mutation impacts.
miRpair2GO allows for the functional comparison of two distinct miRNAs.

Conclusions:

miR2GO provides a valuable resource for researchers studying human miRNA function and mutations.
The platform aids in understanding the biological consequences of miRNA alterations.
miR2GO supports comparative functional genomics research.