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Updated: Apr 16, 2026

Detection of Signaling Effector-Complexes Downstream of BMP4 Using in situ PLA, a Proximity Ligation Assay
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Arkadia enhances BMP signalling through ubiquitylation and degradation of Smad6

Yutaro Tsubakihara1, Atsuhiko Hikita2, Shin Yamamoto3

  • 1Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime; Division of Bio-imaging, Proteo-Science Center, Ehime University, Shitsukawa, Toon, Ehime; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo; Department of Gastroenterology and Metabiology, Ehime University, Shitsukawa, Toon, Ehime; Translational Research Center, Ehime University Hospital, Shitsukawa, Toon, Ehime; and Department of Biochemistry, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan.

Journal of Biochemistry
|March 13, 2015
PubMed

Keywords:
ArkadiaBMPSmad6proteasome-dependent degradationubiquitylation

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