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Synthesis and Characterization of Amphiphilic Gold Nanoparticles
Published on: July 2, 2019
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Microbial mediated preparation, characterization and optimization of gold nanoparticles
Hamed Barabadi1, Soheila Honary1, Pouneh Ebrahimi2
1Mazandaran University of Medical Sciences School of pharmacy Sari Iran Mazandaran University of Medical Sciences, School of pharmacy, Sari, Iran.
Summary
This study biosynthesized gold nanoparticles using Penicillium crustosum fungus, optimizing conditions for eco-friendly, cost-effective production. The developed method enables efficient, scalable synthesis for various applications.
Area of Science:
- Nanotechnology
- Biotechnology
- Materials Science
Background:
- Growing demand for sustainable nanoparticle synthesis methods.
- Limitations of traditional chemical synthesis, including toxic byproducts.
- Potential of biological approaches for eco-friendly nanoparticle production.
Purpose of the Study:
- To biosynthesize and optimize the size of gold nanoparticles using the fungus Penicillium crustosum.
- To explore a cost-effective and environmentally benign method for gold nanoparticle synthesis.
- To establish optimal conditions for gold nanoparticle bioconversion.
Main Methods:
- Biosynthesis of gold nanoparticles using Penicillium crustosum supernatant.
- Characterization using UV-Visible Spectroscopy, Fluorescence, FT-IR, AFM, and DLS.
- Optimization of bioconversion parameters via Box-Behnken experimental design.
Main Results:
- Fairly well-defined gold nanoparticles with good monodispersity were synthesized.
- Key factors influencing synthesis were AuCl₄ concentration, pH, and temperature.
- A high R(2) value of 0.9999 confirmed the accuracy of the polynomial model.
Conclusions:
- Multivariate analysis successfully identified optimal conditions for gold nanoparticle biosynthesis.
- The Penicillium crustosum-mediated method offers a time and cost-effective process.
- This approach is suitable for the mass-scale production of gold nanoparticle formulations.
