Barberry administration and pro-oxidant-antioxidant balance in patients with metabolic syndrome
Akram Mohammadi1, Amirhossein Sahebkar2, Tayyebeh Kermani1
1Biochemistry of Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Background:
Metabolic syndrome is the constellation of several cardiometabolic risk factors, and is associated with a heightened risk of coronary heart disease (CHD). The pro-oxidant-antioxidant balance (PAB) is a measure of factors that promote and control oxidative stress. PAB may also be associated with the risk factors of CHD.
Objectives:
This study aimed to explore the impact of supplementation with barberry, a fruit rich in antioxidants, on PAB in patients with metabolic syndrome.
Patients And Methods:
A total of 106 patients diagnosed with metabolic syndrome were randomized in two groups: case and control. The case group received three capsules of barberry and the control group received three capsules of placebo for 6 weeks. Serum PAB was measured in all patients before and after the intervention.
Results:
There was no significant difference between the groups regarding their baseline PAB values (P = 0.32). A significant decrease in PAB was observed in the barberry group (P = 0.022), whilst there was no significant change in the control group (P = 0.18). The magnitude of change in PAB during the study was significantly greater in the case group compared to the control group (P = 0.01).
Conclusions:
Barberry supplementation reduces oxidative burden in patients with metabolic syndrome.
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