Related Experiment Video
Updated: Aug 15, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
Published on: February 18, 2016
Effects of non-psychotropic drugs on conditioned behavior of cats
1Toxicology and Pharmacology Branch, Food and Drug Administration, Washington, DC 20204.
Abstract:
Cats were trained to obtain food pellets under a cycle reward condition in 4-6 weeks. These conditioned-behavior cats were then used for testing a group of non-psychotropic drugs, and any modification of the feeding cycle (FC) was considered as a side effect of the drug on conditioned behavior. All drugs were given orally. Of the 16 non-psychotropic drugs studied, only indomethacin caused a loss and irregularity in the FC. Antihistamines, acetylsalicylic acid, phenoxybenzamine and amantadine reduced the number of FC by about 50%. Studies of conditioned behavior in the cat appear to be useful for both the investigation of drug interactions and the detection of side effects of drugs not ordinarily considered to have central nervous system effects.
Related Concept Videos
Drugs Affecting Neurotransmitter Release or Uptake
Real-World Application of Classical Conditioning
Higher-order, or second-order, conditioning occurs when a neutral stimulus becomes associated with an already established conditioned stimulus through repeated pairings. For instance, if a dog has been...
Classical Conditioning in Daily Life
John B. Watson and Rosalie Rayner famously demonstrated the development of fear through classical conditioning in their experiment with Little Albert. They paired the...

