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Related Experiment Video

Updated: Apr 16, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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REVERSE 5-year follow up: CRT impact persists.

Mohamed ElMaghawry1, Mahmoud Farouk1

  • 1Department of Cardiology, Aswan Heart Centre, Kasr ElHajjar, Aswan, Egypt.

Global Cardiology Science & Practice
|March 13, 2015
PubMed
Summary

Cardiac resynchronization therapy (CRT) significantly improves outcomes for heart failure patients with mild symptoms. Long-term analysis confirms CRT

Area of Science:

  • Cardiology
  • Heart Failure Management
  • Cardiac Electrophysiology

Background:

  • Previous trials (MIRACLE ICD II, MADIT-CRT, RAFT, REVERSE) demonstrated benefits of cardiac resynchronization therapy (CRT) in heart failure (HF) patients with depressed left ventricular ejection fraction (LV EF) and wide QRS.
  • Observed benefits include reverse cardiac remodeling and reduced HF adverse events, leading to guideline recommendations for CRT in NYHA Class II patients.
  • Further research was recommended to ascertain survival benefits of CRT in mildly symptomatic patients.

Purpose of the Study:

  • To present the 5-year analysis of the REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction (REVERSE) trial.
  • To specifically assess the long-term benefits of CRT in patients with mild heart failure symptoms.

Main Methods:

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  • Prospective, 5-year follow-up study design.
  • Inclusion of patients with mild heart failure manifestations, depressed LV EF, and wide QRS complex.
  • Analysis of data from the REVERSE trial.

    • Main Results:

    • Consistent observed benefits in reverse cardiac remodeling.
    • Reduction in heart failure adverse events.
    • Long-term data from the 5-year REVERSE trial analysis published in the European Heart Journal.

    Conclusions:

    • The 5-year analysis of the REVERSE trial provides further evidence for the long-term benefits of CRT.
    • Findings support the use of CRT in selected NYHA Class II heart failure patients.
    • Continued investigation into survival benefits is warranted.