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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Updated: Apr 16, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Proteomics in pharmaceutical research and development.

Paul Cutler1, Hans Voshol2

  • 1Translational Technologies and Bioinformatics, Pharmaceutical Sciences, Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.

Proteomics. Clinical Applications
|March 13, 2015
PubMed
Summary
This summary is machine-generated.

Proteomics in the pharmaceutical industry has evolved significantly over 20 years, shifting from broad protein profiling to focused drug-protein interaction studies. This review details proteomics

Keywords:
PharmaceuticalProteomicsResearch and development

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Area of Science:

  • Proteomics
  • Pharmaceutical Research
  • Drug Discovery

Background:

  • The pharmaceutical industry's adoption of proteomics has evolved over two decades.
  • Early applications in global protein expression profiling faced challenges.
  • Current trends emphasize focused proteomics approaches, particularly for drug-target interactions.

Purpose of the Study:

  • To review the historical development and current status of proteomics in pharmaceutical research and development.
  • To contextualize the evolution of proteomics technologies within the drug discovery pipeline.
  • To highlight the diverse applications of proteomics in modern pharmaceutical R&D.

Main Methods:

  • Historical review of proteomics applications in the pharmaceutical industry.
  • Analysis of the impact of proteomics on drug discovery and development processes.
  • Synthesis of current trends and contributions to specialized areas like therapeutic protein analysis and clinical trial monitoring.

Main Results:

  • Proteomics has transitioned from broad expression profiling to impactful, focused applications like drug-protein interaction analysis.
  • Proteomics technologies are now integral to various stages of pharmaceutical R&D.
  • The field's evolution reflects advancements in academic and industrial research.

Conclusions:

  • Proteomics plays a crucial role in modern drug discovery and development pipelines.
  • The integration of proteomics has enhanced the analysis of therapeutic proteins and the monitoring of clinical trials.
  • Future directions in proteomics will continue to address diverse demands in drug and biomarker discovery.