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Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents
Prasanna A Datar1, Saleel A Limaye
1Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune - 411041, Maharashtra, India. d_pras_anna@rediffmail.com.
Abstract:
Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium.
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