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Updated: Apr 16, 2026

Imaging and Analysis of Neurofilament Transport in Excised Mouse Tibial Nerve

Imaging and Analysis of Neurofilament Transport in Excised Mouse Tibial Nerve

Published on: August 31, 2020

Diffusion tensor imaging of peripheral nerves.

Ali M Naraghi¹, Haitham Awdeh², Vibhor Wadhwa²

¹Division of Musculoskeletal Radiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, Ontario, Canada.

Seminars in Musculoskeletal Radiology

|March 13, 2015

Summary

Diffusion tensor imaging (DTI) assesses peripheral nerve microstructure. Advances enable DTI in peripheral nerves, overcoming challenges to study nerve pathology.

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Area of Science:

Neuroimaging
Biomedical Engineering
Radiology

Background:

Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique.
DTI excels at analyzing highly anisotropic tissues, like peripheral nerves.
Challenges exist for DTI in peripheral nerves, including artifacts, small nerve size, and low water density.

Purpose of the Study:

To review the principles of DTI.
To examine the application of DTI in peripheral nerve assessment.
To highlight advancements enabling DTI in the peripheral nervous system.

Main Methods:

Review of imaging principles behind DTI.
Examination of existing literature on DTI in peripheral nerves.
Discussion of hardware and software advancements in MRI.

Main Results:

DTI can probe the microstructural environment of peripheral nerves.
Recent MRI advancements facilitate DTI application in the peripheral nervous system.
DTI provides functional data on peripheral nerve pathology.

Conclusions:

DTI is a valuable tool for peripheral nerve assessment.
Technical advancements have overcome previous limitations for peripheral DTI.
DTI aids in understanding the impact of disease on peripheral nerves.