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Changes in pancreatic exocrine secretion after repeated haloperidol administration
J H Pazo1, M I Vaccaro, O R Tumilasci
1Universidad de Buenos Aires, Facultad de Medicina, Departamento de Fisiologia, Buenos Aires, Argentina.
Journal of the Autonomic Nervous System
|December 1, 1989
Summary
Repeated haloperidol treatment significantly increased pancreatic secretion volume and protein in mice. This effect suggests altered dopamine receptor sensitivity in the pancreas following haloperidol administration.
Area of Science:
- Pharmacology
- Gastroenterology
- Neuroendocrinology
Background:
- Haloperidol is a typical antipsychotic drug.
- Pancreatic secretion is crucial for digestion.
- The interaction between antipsychotics and pancreatic function is not well understood.
Purpose of the Study:
- To investigate the effects of repeated haloperidol administration on pancreatic secretion in mice.
- To explore the role of dopamine receptors in mediating these effects.
Main Methods:
- Swiss mice were administered haloperidol (2 mg/kg) daily via intraperitoneal injection for 7 days.
- Basal pancreatic secretion volume and protein content were measured.
- The effects of atropine and bethanechol on pancreatic secretion were assessed in control and treated animals.
Main Results:
- Repeated haloperidol administration significantly increased basal pancreatic juice volume and protein content.
- Atropine partially blocked this secretory activity in both control and treated groups.
- Haloperidol decreased the volume response to bethanechol but did not alter amylase release.
Conclusions:
- Repeated haloperidol treatment enhances basal pancreatic secretion.
- This enhancement is likely due to altered sensitivity of dopamine receptors in the pancreatic gland.
- Further research is needed to elucidate the precise mechanisms involved.