Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Characteristics of hydrogel as disintegrant in solid dose technology.

A R Fassihi1

  • 1Department of Pharmacy, University of the Witwatersrand, Medical School, Parktown, Johannesburg, Republic of South Africa.

The Journal of Pharmacy and Pharmacology
|December 1, 1989
PubMed
Summary

Hydrogels show potential as effective disintegrants in tablets, comparable to common agents like Ac-di-sol and Avicel. This study found no adverse effects on theophylline dissolution or tablet properties, indicating their suitability for pharmaceutical formulations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-marketing drug surveillance--concepts, insights and applications.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1990
Same author

Dissolution of theophylline from film-coated slow release mini-tablets in various dissolution media.

The Journal of pharmacy and pharmacology·1989
Same author

Irritation associated with tear-replacement ophthalmic drops. A pharmaceutical and subjective investigation.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1989
Same author

Influence of gamma radiation on the gel rigidity index and binding capability of gelatin.

Journal of pharmaceutical sciences·1988
Same author

Inimical effects of compaction speed on microorganisms in powder systems with dissimilar compaction mechanisms.

Journal of pharmaceutical sciences·1987

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Drug Delivery

Background:

  • Disintegrants are crucial for tablet efficacy, promoting drug release.
  • Common disintegrants include Ac-di-sol, Avicel, maize starch, and Primojel.
  • Novel materials like hydrogels are being explored for improved formulation performance.

Purpose of the Study:

  • To evaluate the efficacy of a hydrogel as a disintegrant in direct compression tableting.
  • To compare the hydrogel's performance against established disintegrants.
  • To assess the impact of the hydrogel on drug dissolution and tablet properties.

Main Methods:

  • Direct compression tableting using theophylline as a model drug.
  • Comparative analysis with Ac-di-sol, Avicel, maize starch, and Primojel.

Related Experiment Videos

  • Thermal analysis for drug dissolution assessment and scanning electron microscopy (SEM) for structural evaluation.

    • Main Results:

    • The hydrogel exhibited comparable disintegrant action to conventional agents.
    • No adverse effects were observed on theophylline dissolution rates.
    • The hydrogel's integration did not negatively impact the physicomechanical properties of the tablets.
    • SEM revealed the internal structure of the hydrogel, aiding in understanding its function.

    Conclusions:

    • Hydrogels demonstrate significant potential as efficient disintegrants in solid dosage formulations.
    • The studied hydrogel offers a viable alternative to traditional disintegrants.
    • Further research into hydrogel-based formulations is warranted for pharmaceutical applications.