Two new phenolic glucosides from Lagerstroemia speciosa

Area of Science:

• Phytochemistry
• Pharmacology

Background:

• Lagerstroemia speciosa is a plant with potential medicinal properties.
• Phenolic glucosides are a class of compounds known for various biological activities.

Purpose of the Study:

• To isolate and characterize new compounds from Lagerstroemia speciosa.
• To evaluate the inhibitory activity of isolated compounds against nitric oxide production.

Main Methods:

• Isolation of compounds using chromatographic techniques.
• Structure elucidation using 1D- and 2D-NMR, Q-TOF MS, and optical rotation.
• In vitro assay for nitric oxide inhibition in RAW264.7 cells.

Main Results:

• Two new phenolic glucosides, 1-O-benzyl-6-O-E-caffeoyl-β-d-glucopyranoside and 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-β-d-glucopyranoside, were identified.
• Ten known compounds were also isolated from the aerial parts of the plant.
• All isolated compounds demonstrated moderate inhibitory activity against nitric oxide production, with IC50 values ranging from 69.5 to 83.3 μM.

Conclusions:

• Lagerstroemia speciosa is a source of novel phenolic glucosides.
• The isolated compounds possess anti-inflammatory potential by inhibiting nitric oxide production.