Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

6.2K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
6.2K
Tissue Injury: Inflammation and Repair01:28

Tissue Injury: Inflammation and Repair

5.9K
5.9K
Fractures: Bone Repair01:27

Fractures: Bone Repair

6.9K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
6.9K
Phases of Wound Repair01:28

Phases of Wound Repair

9.9K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
9.9K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.2K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.2K
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

4.9K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stage-Specific Collagen V Knockdown Reveals Temporal Control of Fibrillogenesis, Remodeling, and Mechanics in Tendon Healing.

International journal of molecular sciences·2026
Same author

Loss of type III collagen has limited effect on tendon healing in young adult mice.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same author

Tendon-Targeted Knockout of Collagen XII Disrupts Murine Achilles Tendon Structure, Function, and Gene Expression at Later Stages of Postnatal Development.

Annals of biomedical engineering·2026
Same author

Anatomic Total Shoulder Arthroplasty: Long-Term Clinical, Radiographic, and Patient-Reported Outcomes.

The Journal of the American Academy of Orthopaedic Surgeons·2026
Same author

Statistical nonParametric Mapping Enables Rigorous Comparison of Collagen Fibril Diameter Distributions.

Annals of biomedical engineering·2026
Same author

Developmental, but not Homeostatic, Collagen V Expression Regulates Mature Murine Supraspinatus Tendon Structure, Function, and Gene Expression.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026

Related Experiment Video

Updated: Apr 16, 2026

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

2.0K

Tendon basic science: Development, repair, regeneration, and healing.

Nelly Andarawis-Puri1, Evan L Flatow, Louis J Soslowsky

  • 1Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1188, New York, New York, 10029.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|March 13, 2015
PubMed
Summary

This review highlights critical research gaps in tendon injury and healing. Addressing these fundamental biological questions is essential for developing effective tendon therapeutics.

Keywords:
New Frontierstendinopathytendon conferencetendon injury

More Related Videos

Murine Flexor Tendon Injury and Repair Surgery
07:32

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

13.8K
A Protocol to Acquire the Degenerative Tenocyte from Humans
09:25

A Protocol to Acquire the Degenerative Tenocyte from Humans

Published on: June 9, 2018

7.8K

Related Experiment Videos

Last Updated: Apr 16, 2026

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

2.0K
Murine Flexor Tendon Injury and Repair Surgery
07:32

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

13.8K
A Protocol to Acquire the Degenerative Tenocyte from Humans
09:25

A Protocol to Acquire the Degenerative Tenocyte from Humans

Published on: June 9, 2018

7.8K

Area of Science:

  • Orthopedics
  • Musculoskeletal Biology
  • Regenerative Medicine

Background:

  • Tendinopathy and tendon rupture are prevalent, disabling musculoskeletal conditions.
  • Fundamental research into tendon biology, pathogenesis, and healing is limited.
  • Lack of basic science data hinders therapeutic development for tendon injuries.

Purpose of the Study:

  • To identify underdeveloped research areas in tendon science.
  • To foster collaboration between tendon researchers and experts in related fields.
  • To outline essential new research directions for advancing tendon healing.

Main Methods:

  • Review of discussions from the New Frontiers in Tendon Research Conference.
  • Focus on six key topic areas: Cell Biology and Mechanics, Functional Extracellular Matrix, Development, Mechano-biology, Scarless Healing, and Mechanisms of Injury and Repair.
  • Synthesis of insights from review articles within a special issue.

Main Results:

  • Identified significant hurdles and underdeveloped areas in tendon research.
  • Highlighted the need for fundamental data on tendon development, signaling, and mechanotransduction.
  • Emphasized the importance of understanding basic mechanisms of tendon pathogenesis and healing.

Conclusions:

  • Progress in tendon therapeutics requires addressing fundamental biological questions.
  • Interdisciplinary collaboration is crucial for advancing tendon research.
  • This review and special issue aim to guide future research directions in tendon science.