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The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers
Hang Su1, Jingyan Tao2, Jie Zhang2
1Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, SH200025, PR China.
Comprehensive Psychiatry
|March 14, 2015
Summary
Genetic factors, like brain-derived neurotrophic factor (BDNF) gene variations, may influence vulnerability to methamphetamine abuse and impulsivity. A specific BDNF haplotype was linked to lower odds of abuse and altered impulsivity scores.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Genetic factors are increasingly implicated in drug abuse vulnerability.
- Brain-derived neurotrophic factor (BDNF) is a potential candidate gene associated with substance abuse.
Purpose of the Study:
- To investigate the association between BDNF gene polymorphisms and methamphetamine abuse.
- To explore the relationship between these polymorphisms and impulsivity in methamphetamine abusers.
Main Methods:
- Compared three single nucleotide polymorphisms (SNPs) in the BDNF gene (rs16917204, rs16917234, rs2030324) between 200 methamphetamine abusers and 219 controls.
- Assessed impulsivity using the Barratt Impulsivity Scale-11 (BIS-11) Chinese version.
Main Results:
- No significant differences in individual SNP distributions were found between groups.
- A C-C-T haplotype (rs16917204-rs16917234-rs2030324) was significantly associated with a lower odds of methamphetamine abuse.
- Carrying the T allele of rs2030324 was linked to higher motor impulsivity scores in abusers.
Conclusions:
- BDNF gene polymorphisms may play a role in methamphetamine abuse vulnerability.
- Specific BDNF gene variations are associated with impulsivity traits in methamphetamine abusers.
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