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[Implementation of standard operation procedures for KRAS andBRAF gene mutation detection in colorectal cancer]

Lixu Yan, Yanhui Liu1, Xunhua Liu

  • 1E-mail: yanh_liu@163.com.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|March 14, 2015
PubMed
Abstract

No abstract available in PubMed .

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The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
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