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Tuberculosis diagnostics in 2015: landscape, priorities, needs, and prospects
1McGill International TB Centre McGill Global Health Programs, McGill University, Montreal, Canada.
The Journal of Infectious Diseases
|March 14, 2015
Summary
New tuberculosis diagnostics are emerging, but challenges remain in scaling up and developing non-sputum tests for children. Increased funding and government investment are crucial for global tuberculosis control.
Area of Science:
- Global Health
- Infectious Diseases
- Medical Diagnostics
Background:
- Tuberculosis (TB) remains a significant global health challenge in 2015.
- Drug-resistant TB presents an escalating threat to public health.
- Current TB diagnostics in many regions rely on outdated methods.
Purpose of the Study:
- To review the evolving landscape of tuberculosis diagnostics.
- To identify progress and challenges in the development and implementation of new TB diagnostic tools.
- To highlight areas needing further research and investment.
Main Methods:
- Review of the current state of tuberculosis diagnostics development.
- Analysis of the pipeline for new molecular diagnostic tools.
- Examination of initiatives aimed at stimulating product development and policy.
Main Results:
- A promising pipeline exists for new TB diagnostic technologies, with over 50 companies involved.
- New diagnostics have not yet reached widespread implementation.
- Gaps exist in non-sputum-based diagnostics for children and biomarker tests for latent TB infection.
Conclusions:
- Greater alignment is needed between diagnostic development and shorter TB drug regimens.
- Advocacy for increased R&D funding and investment in TB control by high-burden countries is essential.
- Policy and product development initiatives are underway to address TB diagnostic needs.
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