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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Apr 16, 2026

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery
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Cataract surgery and intraocular pressure.

Diana Melancia1, Luis Abegão Pinto, Carlos Marques-Neves

  • 1Department of Pharmacology and Neurosciences, Lisbon University, Lisbon, Portugal.

Ophthalmic Research
|March 14, 2015
PubMed
Summary

Phacoemulsification cataract surgery significantly lowers intraocular pressure (IOP). This review explores patient characteristics predicting IOP reduction, aiding glaucoma and cataract management.

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Surgical Innovation

Background:

  • Cataract surgery, specifically phacoemulsification, is a common procedure worldwide.
  • Emerging evidence suggests phacoemulsification may lower intraocular pressure (IOP).
  • Predictive factors for IOP reduction post-surgery remain largely undefined.

Purpose of the Study:

  • To review existing literature on IOP reduction following cataract surgery.
  • To identify patient characteristics associated with significant IOP decrease.
  • To explore potential mechanisms driving IOP reduction after phacoemulsification.

Main Methods:

  • Systematic literature review of studies investigating IOP changes after cataract surgery.
  • Analysis of patient demographics, ocular parameters, and surgical techniques.

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  • Synthesis of findings regarding IOP-lowering effects and predictive factors.

    • Main Results:

    • Cataract surgery demonstrates a significant and sustained IOP-lowering effect.
    • Specific ocular characteristics influencing IOP reduction are not yet clearly defined.
    • Understanding these factors is crucial for managing patients with co-existing glaucoma and cataracts.

    Conclusions:

    • Phacoemulsification offers a potential IOP-lowering benefit beyond visual acuity improvement.
    • Further research is needed to pinpoint patient profiles most likely to benefit from this effect.
    • Optimizing management strategies for patients with combined glaucoma and cataract is a key objective.