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Related Experiment Video

Updated: Apr 16, 2026

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Screen printed paper-based diagnostic devices with polymeric inks.

Ju-Yen Sun¹, Chao-Min Cheng, Ying-Chih Liao

¹Department of Chemical Engineering, National Taiwan University.

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry

|March 14, 2015

Summary

This summary is machine-generated.

This study presents a low-cost method for creating paper-based diagnostic devices (PBDDs) using screen-printed hydrophobic patterns. These PBDDs enable accurate pH and glucose testing, even with organic solvents.

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Last Updated: Apr 16, 2026

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Area of Science:

Materials Science
Analytical Chemistry
Biomedical Engineering

Background:

Paper-based diagnostic devices (PBDDs) offer a low-cost and accessible platform for point-of-care diagnostics.
Developing simple and reproducible fabrication methods for PBDDs is crucial for their widespread adoption.
Existing methods may involve complex steps or expensive materials, limiting their practicality.

Purpose of the Study:

To develop a simple, low-cost fabrication method for paper-based diagnostic devices (PBDDs).
To demonstrate the functionality of screen-printed hydrophobic patterns for fluidic channels on paper.
To validate the use of these PBDDs for quantitative chemical and biochemical analyses.

Main Methods:

Screen printing of polymer solutions onto filter paper to create hydrophobic patterns.
Dilution of polymer solutions with butyl acetate to achieve optimal viscosity (30-200 cP) for paper patterning.
Colorimetric detection of pH and glucose, followed by computer image analysis for quantification.
Testing with organic solvents (acetone) and simultaneous detection of multiple analytes.

Main Results:

Successfully fabricated functional hydrophobic fluidic channels on paper using screen printing.
Achieved accurate calibration curves for pH (2-12) and glucose (10-1000 mmol dm(-3)).
Demonstrated the capability for detecting formaldehyde in acetone, showcasing utility with organic solvents.
Exemplified simultaneous pH and glucose detection for realistic diagnostic scenarios.

Conclusions:

The screen printing method provides a simple and cost-effective approach for fabricating PBDDs.
The developed PBDDs are suitable for quantitative analysis of various analytes, including those in organic solvents.
This technique holds significant potential for developing practical and accessible diagnostic tools.