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Updated: Apr 16, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Parent and public interest in whole-genome sequencing
Daniel S Dodson1, Aaron J Goldenberg, Matthew M Davis
1Child Health Evaluation and Research (CHEAR) Unit, University of Michigan, Ann Arbor, Mich., USA.
Public interest in whole-genome sequencing (WGS) is significant for both self and children. Parents show similar WGS interest levels for themselves and their youngest children, influenced by factors like health and political ideology.
Area of Science:
- Genomic Medicine
- Public Health Genetics
Background:
- Whole-genome sequencing (WGS) offers comprehensive genetic information.
- Understanding public interest is crucial for WGS implementation in healthcare.
Purpose of the Study:
- To assess public interest in WGS for personal use.
- To evaluate parental interest in WGS for their children.
- To identify factors influencing this interest.
Main Methods:
- A nationally representative online survey of adults was conducted.
- Participants received information about WGS before expressing interest.
- Parents were surveyed about interest in WGS for themselves and their children.
Main Results:
- 58.6% of adults were interested in WGS for themselves.
- 61.8% of parents were interested in WGS for themselves, and 57.8% for their children.
- Mothers and parents of children with multiple health conditions showed higher interest; conservative ideologies correlated with lower interest.
Conclusions:
- US adults show considerable interest in WGS, with parents mirroring interest for themselves and their children.
- Clinicians must be prepared to discuss WGS, its risks, and benefits as it becomes more accessible.
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