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Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
Published on: September 14, 2014
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HIV-gp120 and physical dependence to buprenorphine
J Palma1, M E Abood1, K Benamar2
1Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, United States.
Drug and Alcohol Dependence
|March 14, 2015
Summary
Buprenorphine may be a better treatment for opioid dependence in individuals with HIV. Studies show HIV-1 gp120 did not worsen buprenorphine withdrawal symptoms in rats.
Area of Science:
- Neuroscience
- Pharmacology
- Infectious Disease
Background:
- Opioids are effective analgesics but cause dependence.
- Opioid dependence in HIV-infected individuals presents unique challenges.
- Understanding opioid dependence in the context of HIV is crucial for effective treatment.
Purpose of the Study:
- To investigate the physical dependence potential of buprenorphine in the context of HIV.
- To assess the impact of HIV-1 envelope glycoprotein 120 (gp120) on opioid dependence.
Main Methods:
- Young adult male Sprague-Dawley rats were used.
- Rats were pretreated with HIV-1 gp120 injected into the periaqueductal gray (PAG).
- Physical dependence to opioids was examined.
Main Results:
- Physical dependence to methadone developed earlier than to buprenorphine.
- HIV-1 gp120 did not enhance or precipitate buprenorphine withdrawal.
- Buprenorphine withdrawal was not affected by gp120.
Conclusions:
- Buprenorphine may be a more suitable therapeutic option for managing opioid dependence in HIV-positive patients.
- These findings support buprenorphine's potential role in HIV-associated opioid use disorder treatment.
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