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Related Experiment Video

Updated: Apr 16, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

Primary renal primitive neuroectodermal tumor.

V Goel¹, V Talwar, C Dodagoudar

¹Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India.

Journal of Postgraduate Medicine

|March 14, 2015

Summary

This summary is machine-generated.

Primitive Neuroectodermal Tumor (PNET) of the kidney is rare. This case highlights the importance of prompt diagnosis and effective chemotherapy for this aggressive renal tumor.

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Area of Science:

Oncology
Pathology

Background:

Primary renal Primitive Neuroectodermal Tumor (rPNET) is an exceptionally rare condition.
Existing literature primarily consists of isolated case reports.

Observation:

A 39-year-old male presented with a suspected renal cell carcinoma and renal vein thrombosis.
Histopathological examination revealed a highly aggressive tumor with monotonous sheets of round cells.

Findings:

Immunohistochemical analysis confirmed the diagnosis of rPNET, with tumor cells positive for CD 99 and FLI-1.
The patient underwent radical nephrectomy with thrombolectomy followed by VAC/IE-based adjuvant chemotherapy.

Implications:

Accurate and timely diagnosis of rPNET is crucial due to its aggressive nature.
Differentiating rPNET from other small round-cell tumors is essential for selecting appropriate therapeutic strategies.