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Updated: Apr 16, 2026

Author Spotlight: Decoding Mitochondrial Aging
Published on: June 30, 2023
The role of mitochondrial DNA mutation on neurodegenerative diseases
Moon-Yong Cha1, Dong Kyu Kim1, Inhee Mook-Jung1
1Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.
Abstract:
Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.
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