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Nuclear factor of activated T cells in cancer development and treatment

Jiawei Shou1, Jing Jing2, Jiansheng Xie3

  • 1Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Cancer Letters
|March 14, 2015
PubMed

Insights

Nuclear factor of activated T cells (NFAT) plays a role in various cancers. Understanding NFAT regulation and function is key for developing novel cancer therapies and prevention strategies.

Area of Science:

  • Molecular biology
  • Immunology
  • Oncology

Background:

  • Nuclear factor of activated T cells (NFAT) was initially identified as a T-cell transcription factor.
  • Multiple NFAT isoforms have been discovered, with diverse roles.
  • NFAT signaling is implicated in various cancer hallmarks.

Purpose of the Study:

  • To review the current understanding of NFAT regulation and function in cancer.
  • To explore the role of NFAT in cancer development and treatment.
  • To highlight NFAT as a potential therapeutic target.

Main Methods:

  • Literature review of studies on NFAT in cancer.
  • Analysis of NFAT isoforms' functions in different cancer types.
  • Examination of NFAT's role in carcinogenesis, proliferation, metastasis, drug resistance, and the tumor microenvironment.

Main Results:

  • NFAT isoforms exhibit distinct functions depending on the cancer type and context.
  • NFAT activity is crucial in multiple stages of cancer progression.
  • The precise role of NFAT in cancer and the tumor microenvironment is context-specific.

Conclusions:

  • NFAT signaling is a significant factor in cancer development and progression.
  • NFATs represent a promising target for novel cancer prevention and therapeutic strategies.
  • Further research into NFAT's context-dependent functions can optimize cancer treatment.
Keywords:
CalcineurinDrug resistanceMetastasisNFATTumor microenvironment

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