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Related Experiment Videos

[Vasoactive intestinal polypeptide: a potential neurotransmitter].

D Zudenigo, Z Lacković

    Lijecnicki Vjesnik
    |September 1, 1989
    PubMed
    Summary

    Vasoactive intestinal polypeptide (VIP) plays key roles in the nervous system and periphery, influencing functions like vasodilation and hormone secretion. Further research into VIP is needed, as effective therapeutic agents are not yet available.

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    Area of Science:

    • Neuroscience
    • Endocrinology
    • Physiology

    Context:

    • Vasoactive intestinal polypeptide (VIP) is a peptide hormone with widespread distribution in the central and peripheral nervous systems.
    • VIP-ergic neurons are found in various organs, including the heart, lungs, digestive tract, and brain.
    • Its functions extend to regulating blood flow, smooth muscle activity, exocrine secretion, and hormone release.

    Purpose:

    • To review current advances in the anatomy, physiology, and pharmacology of VIP.
    • To elucidate the distribution and functions of VIP in the central and peripheral nervous systems.
    • To discuss the potential implications of VIP in disease and therapeutic strategies.

    Summary:

    • VIP is a 28-amino acid peptide found in nerves throughout the body and brain.
    • It mediates effects such as vasodilation, smooth muscle relaxation, and hormone secretion.
    • VIP-ergic neurons are implicated in cortical energy metabolism, pain transmission, and autonomic reflexes.

    Impact:

    • Understanding VIP's roles can provide insights into various physiological processes and diseases.
    • The lack of effective non-polypeptide agonists and antagonists currently limits practical clinical applications.
    • Future development of VIP-targeting drugs could offer novel therapeutic avenues.

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