Bioadhesive films containing fluconazole for mucocutaneous candidiasis

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Fluconazole is a broad-spectrum antifungal agent used for candidiasis.
• Systemic toxicity and drug-drug interactions limit fluconazole use.
• Localized delivery can enhance efficacy and reduce side effects.

Purpose of the Study:

• To formulate and evaluate bioadhesive films for controlled local delivery of fluconazole.
• To reduce systemic toxicity by targeting drug delivery to the infection site.

Main Methods:

• Bioadhesive films prepared using sodium alginate and polyvinyl alcohol via solvent casting.
• Films evaluated for physical properties, swelling, pH, folding endurance, and bioadhesion.
• In vitro drug release, ex vivo residence time, and skin irritation studies conducted.
• Optimized formulation stability assessed per ICH guidelines.

Main Results:

• Films exhibited suitable physical characteristics (weight < 20 mg, thickness 0.09-0.15 mm).
• Bioadhesive strength exceeded 18 g, with ex vivo residence time over 5 hours.
• Controlled drug release observed for up to 8 hours.
• FT-IR and DSC studies confirmed drug-excipient compatibility.

Conclusions:

• Bioadhesive films provide a promising platform for localized, controlled delivery of fluconazole.
• This approach can potentially minimize systemic toxicity and improve treatment outcomes for candidiasis.