Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.9K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.9K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

2.3K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Folic acid-functionalized PEGylated magnetic nanocarriers for targeted delivery of curcumin to inflamed tissues.

The Journal of pharmacy and pharmacology·2026
Same author

Antibacterial Packaging for Cheese Based on Carboxymethyl Cellulose Composite with Zinc Oxide and Thyme Essential Oil.

Foods (Basel, Switzerland)·2026
Same author

Critical Role of Molecular-Based Stratification in Low-Risk Myelodysplastic Syndrome with Direct Progression to Acute Myeloid Leukemia: A Case Report.

International journal of molecular sciences·2026
Same author

Physico-Chemical and Biological Evaluation of Spin-Coated Chromium-Doped Hydroxyapatite in Dextran Matrix Coatings.

Biomimetics (Basel, Switzerland)·2026
Same author

Process Engineering Strategies for Microbial Lipid Production: From Strain Evolution to Industrial-Scale Bioprocessing.

International journal of molecular sciences·2026
Same author

Comparison of five different Light-Cured Pulp Capping Materials to a Hydraulic Calcium Silicate Cement: A Long-Term Physicochemical Study.

International dental journal·2026

Related Experiment Video

Updated: Apr 16, 2026

Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration
08:55

Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration

Published on: July 6, 2022

2.5K

Antitumoral materials with regenerative function obtained using a layer-by-layer technique.

Denisa Ficai1, Maria Sonmez2, Madalina Georgiana Albu3

  • 1Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, Bucharest, Romania.

Drug Design, Development and Therapy
|March 14, 2015
PubMed
Summary

This study developed collagen/hydroxyapatite-magnetite-cisplatin composite materials for bone cancer treatment. These materials offer controlled drug delivery and enhanced bone healing, with potential for electromagnetic activation against tumors.

Keywords:
antitumoral activitybone graftsmultifunctional materialsscaffold

More Related Videos

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

15.3K
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

9.3K

Related Experiment Videos

Last Updated: Apr 16, 2026

Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration
08:55

Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration

Published on: July 6, 2022

2.5K
Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

15.3K
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

9.3K

Area of Science:

  • Biomaterials Science
  • Oncology
  • Nanotechnology

Background:

  • Bone cancer treatment faces challenges with drug delivery and tissue regeneration.
  • Developing multifunctional biomaterials is crucial for effective cancer therapy and patient recovery.

Purpose of the Study:

  • To synthesize and characterize collagen/hydroxyapatite-magnetite-cisplatin (COLL/HAn-Fe3O4-CisPt) composite materials.
  • To evaluate the potential of these composites for targeted bone cancer treatment.
  • To investigate the role of hydroxyapatite content in drug delivery and antitumoral efficacy.

Main Methods:

  • Layer-by-layer fabrication of COLL/HAn-Fe3O4-CisPt composites with varying hydroxyapatite content.
  • In vitro cytotoxicity assays to assess antitumoral activity.
  • Analysis of cisplatin absorption and content within the composite matrices.

Main Results:

  • Successful synthesis of COLL/HAn-Fe3O4-CisPt composite materials.
  • Demonstrated in vitro antitumoral activity of the composites.
  • Higher hydroxyapatite content correlated with increased cisplatin absorption and enhanced antitumoral efficacy.

Conclusions:

  • COLL/HAn-Fe3O4-CisPt composites show promise for bone cancer treatment.
  • The materials facilitate controlled release of chemotherapeutics and support bone healing.
  • Hydroxyapatite content is a key factor in optimizing the therapeutic performance of these novel biomaterials.