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Cavernomas: Outcomes after gamma-knife radiosurgery in Iran
Parisa Azimi1, Sohrab Shahzadi1, Mohammad Ali Bitaraf2
1Department of Neurosurgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gamma-knife surgery (GKS) offers a safe and effective treatment for cavernomas, especially in surgically difficult areas. Low-dose GKS demonstrates significant benefits for managing these brain vascular malformations.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Neurology
Background:
- Cavernomas in surgically inaccessible locations present significant treatment challenges.
- Gamma-knife surgery (GKS) is an advanced radiosurgical technique for treating brain lesions.
Purpose of the Study:
- To evaluate the safety and efficacy of Gamma-knife surgery (GKS) for treating cavernomas.
- To assess hemorrhage rates, complications, and radiation effects following GKS.
Main Methods:
- Retrospective review of 100 patients treated with GKS between 2003 and 2011.
- Stratification of patients based on marginal tumor dose: ≤13 Gy versus >13 Gy.
- Analysis of demographic data, clinical characteristics, hemorrhage rates, and complications.
Main Results:
- A median reduction of 27.5% in cavernoma size was observed.
- Hemorrhage rates were 4.1% within the first 2 years and 1.9% thereafter.
- Treatment-related morbidity was 12%; radiation complications occurred at a marginal dose of 13 Gy.
Conclusions:
- GKS is a safe and beneficial treatment option for carefully selected patients with cavernomas.
- Low-dose GKS shows promise as an effective management strategy for cavernous malformations.
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