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Nano-enabled SERS reporting photosensitizers.

Arash Farhadi1, Áron Roxin2, Brian C Wilson1

  • 11. Princess Margaret Cancer Centre, UHN, Toronto, Ontario, Canada ; 2. Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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|March 14, 2015
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Summary

This study introduces nano-enabled surface-enhanced Raman scattering (SERS) for monitoring palladium-photosensitizers in photodynamic therapy (PDT). This technique allows for real-time dosimetry, optimizing both treatment and imaging.

Keywords:
DosimetryNanoparticlesPDTPorphyrinsSERSTheranostics

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Photodynamic Therapy

Background:

  • Effective photodynamic therapy (PDT) requires precise control of light dose and photosensitizer concentration.
  • In vivo photosensitizer monitoring traditionally relies on fluorescence, which is undetectable for promising palladium-containing agents.
  • Palladium-photosensitizers offer high PDT efficacy but lack a reliable in vivo monitoring method.

Purpose of the Study:

  • To develop a novel method for monitoring palladium-photosensitizers in real-time during PDT.
  • To couple plasmonic nanoparticles with palladium-photosensitizers to enable SERS reporting.
  • To enable independent optimization of therapeutic and imaging mechanisms in PDT.

Main Methods:

  • Coupling plasmonic nanoparticles with palladium-photosensitizers.
  • Utilizing surface-enhanced Raman scattering (SERS) for molecular reporting and monitoring.
  • Employing the same laser wavelength for both PDT stimulation and SERS imaging.

Main Results:

  • Demonstrated that nano-enabled SERS provides reporting and monitoring capabilities for palladium-photosensitizers.
  • Achieved decoupling of therapeutic and imaging functions, allowing independent optimization.
  • Enabled simultaneous stimulation of PDT and imaging features with a single laser wavelength.

Conclusions:

  • Nano-enabled SERS reporting offers a viable solution for monitoring otherwise non-fluorescent palladium-photosensitizers.
  • This approach facilitates real-time dosimetry of photosensitizer concentration and PDT dose delivery.
  • The technology holds potential for optimizing PDT efficacy and safety through precise monitoring.