Meningeal involvement in multiple myeloma.

Area of Science:

• Oncology
• Neurology

Background:

• Multiple myeloma is a hematologic malignancy.
• Nasopharyngeal masses can be a rare presentation of multiple myeloma.

Observation:

• A patient with multiple myeloma presented with a nasopharyngeal mass.
• Initial treatment with melphalan autograft and radiotherapy achieved complete remission.

Findings:

• The patient relapsed 3 months later with isolated meningeal involvement.
• Intrathecal and systemic chemotherapy failed to improve neurological status.
• The patient died 4 weeks after relapse.

Implications:

• This case underscores the aggressive nature of certain multiple myeloma relapses.
• Isolated meningeal involvement in multiple myeloma carries a poor prognosis.
• Further research into novel therapeutic strategies for meningeal carcinomatosis is warranted.