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IgG4-Related Nasal Pseudotumor.
L K Døsen1, P Jebsen2, B Dingsør3
1Department of Otorhinolaryngology, Lovisenberg Diakonale Hospital, 0440 Oslo, Norway.
Case Reports in Otolaryngology
|March 14, 2015
Summary
Immunoglobulin G4-related disease (IgG4-RD) can manifest in the nasal cavity, presenting as symmetrical lesions. These findings highlight IgG4-related disease as a potential cause of nasal obstruction.
Area of Science:
- Immunology
- Otolaryngology
- Pathology
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognized fibroinflammatory condition.
- While commonly associated with autoimmune pancreatitis, IgG4-RD affects multiple organs.
- Nasal involvement in IgG4-RD has been infrequently reported.
Purpose of the Study:
- To describe novel symmetrical nasal lesions in two patients.
- To characterize the histopathological features of these nasal lesions.
- To discuss the implications of IgG4-RD in sinonasal pathology.
Main Methods:
- Case presentation of two patients with nasal lesions.
- Histopathological examination of biopsy specimens.
- Immunohistochemical staining for IgG4 positive plasma cells.
Main Results:
- Two patients presented with symmetrical nasal lesions involving the anterior nasal septum and lateral nasal walls.
- Histology revealed fibrosis and lymphoplasmacytic infiltrations.
- Abundant IgG4 positive plasma cells were identified in the lesions.
- Lesions caused severe nasal obstruction due to extension into the nasal vestibulum.
Conclusions:
- Symmetrical nasal lesions can be a manifestation of IgG4-related disease.
- IgG4-RD should be considered in the differential diagnosis of sinonasal fibrosis and lymphoplasmacytic infiltrations.
- Early recognition and diagnosis are crucial for appropriate management of IgG4-related disease in the nasal cavity.
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