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Updated: Apr 16, 2026

Engineering Platform and Experimental Protocol for Design and Evaluation of a Neurally-controlled Powered Transfemoral Prosthesis
Published on: July 22, 2014
Benefits for Adults with Transfemoral Amputations and Peripheral Artery Disease Using Microprocessor Compared with
Christopher Kevin Wong1, John Rheinstein, Michelle A Stern
1From the Department of Rehabilitation & Regenerative Medicine, Columbia University Medical Center, New York (CKW); Hanger Clinic, New York (JR); and Department of Rehabilitation at Jacobi Medical Center/North Central Bronx Hospital and Albert Einstein College of Medicine, Bronx, New York (MAS).
Objective:
Approximately 50% of people with leg amputation fall annually. Evidence suggests that microprocessor knees (MK) may decrease falls and improve prosthetic function in people with traumatic amputations. This study explored whether adults with transfemoral amputations and peripheral artery disease would have reduced falls and improved balance confidence, balance, and walking ability when using prostheses with MK compared with non-MK.
Design:
This was a prospective cohort study.
Results:
Eight subjects averaged 60.8 ± 11.3 yrs or age and 9.5 ± 16.1 yrs since first amputation. Four were K1-K2-level and four were K3-level functional walkers; only Houghton prosthetic use score was different between K1-K2 and K3 walkers (P = 0.03). After 48.3 ± 38.1 wks of acclimation using MK, subjects demonstrated improvements in fear of falling, balance confidence, Timed Up-and-Go time, and rate of falls (P < 0.05). The improvements in fear of falling, balance confidence, and rate of falls had large effect sizes (d > 0.80). Average decreased Timed Up-and-Go time (12.3 secs) had a medium effect size (d = 0.34). Decreases in the number of falls correlated with faster Timed Up-and-Go speed (ρ = -0.76) and greater balance confidence (ρ = 0.83).
Conclusions:
People with peripheral artery disease and transfemoral amputations had fewer falls and improved balance confidence and walking performance when using prostheses with MK.
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