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Connectome and schizophrenia.

Katherine L Narr1, Amber M Leaver

  • 1aAhmanson-Lovelace Brain Mapping Center, Department of Neurology bDepartment of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California, USA.

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Summary
This summary is machine-generated.

Schizophrenia is characterized by altered brain connectivity, impacting function and cognition. Advanced imaging reveals insights into the human connectome, offering potential for improved diagnosis and treatment.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • The human connectome, comprising neural networks, is vital for brain function.
  • Disruptions in these networks can lead to behavioral changes and brain dysfunction.
  • Schizophrenia is increasingly understood as a disorder involving altered brain connectivity.

Purpose of the Study:

  • To review recent advancements in imaging techniques for studying the structural and functional connectome in schizophrenia.
  • To highlight how these methods address alterations in brain networks in patients with schizophrenia.

Main Methods:

  • Utilized structural, diffusion, and functional (resting-state and task-related) imaging.
  • Employed advanced computational analyses, including graph theory.
  • Synthesized findings from over 200 recent publications.

Main Results:

  • Studies reveal differences in brain networks between schizophrenia patients and controls.
  • Investigated the relationship between connectivity, symptom profiles, and cognitive impairments.
  • Explored the role of the connectome in conferring genetic risk for schizophrenia.

Conclusions:

  • Schizophrenia is strongly supported as a disorder of altered brain connectivity.
  • Characterizing the connectome advances understanding of neurobiology, clinical symptoms, and cognitive deficits.
  • While clinical utility is pending, connectome research promises improved diagnosis, treatment, and outcomes.