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Early morphea simulating patch-stage mycosis fungoides.

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Early morphea can mimic mycosis fungoides (MF), leading to misdiagnosis. Careful clinicopathologic evaluation over time is crucial for accurate diagnosis of morphea.

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Area of Science:

  • Dermatopathology
  • Dermatology
  • Fibrosing skin conditions

Background:

  • Morphea is a rare fibrosing skin condition characterized by thickened collagen, loss of adnexal structures, and fat trapping.
  • Early morphea may lack definitive histopathologic features, causing diagnostic challenges.

Observation:

  • An unusual case of early morphea was initially misdiagnosed as patch-stage poikilodermatous mycosis fungoides (MF).
  • The misdiagnosis was based on initial clinical, histopathologic, and molecular findings.

Findings:

  • Over time, the lesions evolved, revealing characteristic clinical and histopathologic features of morphea.
  • This case highlights the potential for early morphea to simulate MF.

Implications:

  • Dermatologists and dermatopathologists must exercise caution when differentiating early morphea from MF.
  • Awareness of this simulation is critical to avoid diagnostic errors and ensure appropriate patient management.