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[The effect of parenteral gold preparations on heart function in rheumatoid arthritis patients (based on

E N Nemchinov, N V Chichasova, M Z Kanevskaia

    Revmatologiia (Moscow, Russia)
    |October 1, 1989
    PubMed

    Insights

    Parenteral gold preparations, chrisanolum and myocrisin, showed positive effects in rheumatoid arthritis (RA) patients. Treatment improved heart function and reduced disease symptoms over two years.

    Area of Science:

    • Rheumatology
    • Cardiology
    • Pharmacology

    Background:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
    • RA can affect various organs, including the heart.
    • Gold compounds have been used historically for RA treatment.

    Purpose of the Study:

    • To evaluate the efficacy of parenteral chrisanolum and myocrisin in RA patients.
    • To assess the impact of gold therapy on cardiac function in RA.
    • To determine the effect on clinical and laboratory markers of RA.

    Main Methods:

    • A cohort of 30 RA patients received treatment.
    • Treatment involved parenteral administration of chrisanolum and myocrisin.
    • The study duration exceeded two years.

    Main Results:

    • Parenteral gold preparations demonstrated a clear positive effect on cardiac contractile and pumping function.
    • Significant decrease in clinical manifestations of RA was observed.
    • Laboratory markers of rheumatoid arthritis also showed improvement.

    Conclusions:

    • Parenteral gold therapy, including chrisanolum and myocrisin, is beneficial for RA patients.
    • Gold compounds can improve cardiac function in RA.
    • These preparations effectively reduce RA disease activity.

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