Related Experiment Video
Updated: Apr 16, 2026
08:09
Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
8.1K
Parkinson's disease and enhanced inflammatory response.
Iva Stojkovska1, Brandon M Wagner1, Brad E Morrison2
1Department of Biological Sciences, Boise State University, Boise, ID 83725-1515, USA.
Experimental Biology and Medicine (Maywood, N.J.)
|March 15, 2015
Summary
Parkinson's disease (PD) involves the loss of brain cells. This review explores how inflammation may cause this neurodegenerative condition and its progression.
Area of Science:
- Neuroscience
- Immunology
- Neurology
Background:
- Parkinson's disease (PD) is a leading neurodegenerative disorder.
- The loss of midbrain dopaminergic (DA) neurons causes PD symptoms.
- The precise molecular triggers for DA neuron degeneration are not fully understood.
Purpose of the Study:
- To review current research linking Parkinson's disease and inflammation.
- To examine the role of inflammatory responses in PD pathogenesis.
Main Methods:
- Literature review of studies on Parkinson's disease and inflammation.
- Analysis of research connecting neuroinflammation and dopaminergic neuron loss.
Main Results:
- Growing evidence suggests a significant role for inflammation in PD.
- Inflammatory processes are implicated in the development and progression of PD pathology.
Conclusions:
- Inflammation is a key factor in Parkinson's disease.
- Further research into the PD-inflammation connection is warranted.
Related Concept Videos
01:15Parkinson's Disease: Overview
2.5K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.5K
01:24Parkinson's Disease: Treatment
1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
01:37Neural Regulation
45.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
45.1K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.2K
01:28Inflammatory Response
19.7K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
19.7K
01:20COPD: Pathogenesis and Clinical Features
2.2K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.2K