Related Experiment Video
Updated: Apr 16, 2026
Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Clinical utility of hepatic-perfusion computerized tomography in living-donor liver transplantation: a preliminary
M Kantarci1, B Pirimoglu1, G Ozturk2
1Department of Radiology, School of Medicine, Atatürk University, Erzurum, Turkey.
Insights
Perfusion CT imaging offers a noninvasive method to quantitatively assess vascular complications in liver transplant grafts. This technique aids in evaluating treatment response and graft health after living-donor liver transplantation (LDLT).
Area of Science:
- Radiology
- Transplant Surgery
- Hepatology
Background:
- Vascular complications occur in 9% of liver transplant recipients.
- Conventional imaging lacks quantitative assessment of graft hepatocyte damage.
- Perfusion CT enables quantitative hemodynamic evaluation of liver tissue.
Purpose of the Study:
- To evaluate the clinical utility of perfusion CT in assessing vascular complications.
- To assess graft parenchyma after living-donor liver transplantation (LDLT).
Main Methods:
- 33 recipients were grouped by Doppler ultrasonography findings.
- Calculated blood volume (BV), blood flow (BF), arterial liver perfusion (ALP), portal venous perfusion (PVP), and hepatic perfusion index (HPI).
- Evaluated affected vascular territory regions compared to normal parenchyma.
Main Results:
- Hepatic arterial complication group showed lower BV, BF, ALP, and HPI.
- Portal venous complication group had lower PVP and BV, but higher ALP, HPI, and BF.
- Hepatic venous complication group exhibited higher PVP and lower BF, ALP, and HPI.
Conclusions:
- Perfusion CT is a noninvasive technique for quantitative evaluation of graft vascular complications post-LDLT.
- It allows for quantitative assessment of treatment response.
- This method aids in monitoring liver graft health.
Background:
Vascular complications are a primary diagnostic consideration in liver transplant recipients, with an overall incidence of 9%. Cross-sectional imaging techniques provide information regarding vascular structure and luminal patency but can not quantitatively assess hepatocyte damage in the liver graft parenchyma. Perfusion computerized tomography (CT) is a recently developed method that allows for quantitative evaluation of hemodynamic changes in tissue. Our objective was to evaluate the clinical utility of perfusion CT in assessing vascular complications during living-donor liver transplantation (LDLT).
Methods:
The 33 recipients were divided into 3 groups according to Doppler ultrasonographic findings: hepatic arterial complication group, portal venous complication group, and hepatic venous complication group. Blood volume (BV), blood flow (BF), arterial liver perfusion (ALP), portal venous perfusion (PVP), and hepatic perfusion index (HPI) were calculated for the affected vascular territory regions.
Results:
Compared with normal liver parenchyma, BV, BF, ALP, and HPI were significantly lower in the hepatic arterial complication group. Although PVP and BV were significantly lower, ALP, HPI, and BF were higher in the affected vascular territory region than in normal liver parenchyma for the portal venous complication group. In the hepatic venous complication group, PVP was significantly higher and BF, ALP, and HPI significantly lower in the affected vascular territory regions than in normal liver parenchyma.
Conclusions:
Perfusion CT imaging is a noninvasive technique that enables the quantitative evaluation of vascular complications in the graft parenchyma after LDLT and permits a quantitative evaluation of the treatment response.
