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Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
Published on: July 13, 2014
[Sudden death from coronary thrombosis and myocardial infarct correlated with blood alcohol]
Insights
This study examined 402 sudden cardiac deaths, finding alcohol (alcoholemia) was present in 11.3% of coronary thromboses and 19.5% of recent myocardial infarctions, suggesting a link.
Area of Science:
- Forensic Pathology
- Cardiology
- Toxicology
Context:
- Sudden cardiac death is a significant public health concern.
- Medicolegal autopsies provide crucial data on causes of death.
- Alcohol consumption is a known risk factor for cardiovascular disease.
Purpose:
- To investigate the prevalence of alcohol (alcoholemia) in sudden cardiac deaths.
- To determine the association between alcohol presence and specific coronary events like thrombosis and myocardial infarction.
Summary:
- Analysis of 3,786 autopsies, including 402 sudden cardiac deaths.
- Histologic examination and toxicologic tests (alcoholemia) were performed.
- Alcohol was detected in 11.3% of coronary thromboses and 19.5% of recent myocardial infarctions.
Impact:
- Findings suggest a potential correlation between alcohol consumption and specific causes of sudden cardiac death.
- Highlights the importance of toxicologic screening in autopsy protocols for cardiac fatalities.
- Contributes to understanding the multifactorial nature of sudden cardiac death.
Abstract:
The authors analyze the medicolegal files including 3,786 consecutive autopsies, of which 402 sudden coronary cardiac deaths. Autopsy was completed by histologic examination and toxicologic tests (alcoholemia). In the category of coronary cardiac sudden deaths there were 53 coronary thromboses (13.2%) and 36 recent myocardial infarction (8.95%). In 1,196 (31.6%) of 3,786 alcoholemia determinations the results were positive in 111 (27.6%), the difference between the two frequencies not being statistically significant (t less than 1.96). Alcoholemia was positive in 6 of 53 cases of coronary thromboses (11.3%, p less than 0.01), and in 36 cases of recent myocardial infarction alcoholemia was positive in 7 cases (19.5%; t less than 1.96).
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