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Updated: Apr 16, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

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CCR 20th anniversary commentary: BMS-247550—microtubule stabilization as successful targeted therapy

Navjotsingh Pabla1, Alex Sparreboom2

  • 1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|March 15, 2015
PubMed

Insights

Ixabepilone demonstrated anticancer activity in preclinical studies and clinical trials. This led to its approval for treating advanced, drug-resistant breast cancers.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • BMS-247550 (ixabepilone) exhibits anticancer properties.
  • Preclinical studies showed efficacy against taxane-sensitive and resistant cancers.

Purpose of the Study:

  • To summarize the development and approval of ixabepilone.
  • To highlight its role in treating resistant breast cancers.

Main Methods:

  • Review of preclinical studies on BMS-247550.
  • Analysis of subsequent clinical trials evaluating ixabepilone efficacy.

Main Results:

  • Demonstrated anticancer activity in preclinical models.
  • Established clinical efficacy in patients with resistant breast cancers.

Conclusions:

  • Ixabepilone is an effective treatment for drug-resistant metastatic or locally advanced breast cancers.
  • Regulatory approval signifies its clinical importance.

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