Related Experiment Video

Updated: Apr 16, 2026

Tick Microbiome Characterization by Next-Generation 16S rRNA Amplicon Sequencing
07:21

Tick Microbiome Characterization by Next-Generation 16S rRNA Amplicon Sequencing

Published on: August 25, 2018

13.6K

Infections with the tick-borne bacterium Candidatus Neoehrlichia mikurensis

C Wennerås1

  • 1Department of Clinical Microbiology at Sahlgrenska University Hospital, Göteborg, Sweden; Department of Infectious Diseases at Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|March 16, 2015
PubMed

Insights

Candidatus Neoehrlichia mikurensis is an emerging tick-borne bacterium causing neoehrlichiosis. This underdiagnosed infection poses severe risks, especially for immunocompromised individuals, due to potential vascular events.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Candidatus Neoehrlichia mikurensis is an emerging tick-borne pathogen with rodents as natural hosts.
  • It causes the intracellular bacterial infection neoehrlichiosis, prevalent in Europe and Asia.
  • Neoehrlichiosis is often underdiagnosed due to limitations in routine culture-based detection methods.

Purpose of the Study:

  • To highlight the significance of Candidatus Neoehrlichia mikurensis as an emerging pathogen.
  • To underscore the diagnostic challenges and underdiagnosis of neoehrlichiosis.
  • To emphasize the severe clinical manifestations in immunocompromised patients.

Main Methods:

  • Literature review on Candidatus Neoehrlichia mikurensis and neoehrlichiosis.
  • Analysis of diagnostic limitations of current detection methods.
  • Review of clinical case reports focusing on severe neoehrlichiosis.

Main Results:

  • Candidatus Neoehrlichia mikurensis is a growing concern in Europe and Asia.
  • Immunocompromised individuals are at risk for severe neoehrlichiosis, including fever and thromboembolic events.
  • Current diagnostic methods fail to detect the bacterium, leading to underdiagnosis.

Conclusions:

  • Neoehrlichiosis requires increased clinical awareness and improved diagnostic strategies.
  • Early detection and treatment are crucial, particularly for at-risk populations.
  • Further research is needed to develop effective diagnostic and therapeutic approaches for neoehrlichiosis.
Keywords:
Candidatus Neoehrlichia mikurensisimmunocompromisedneoehrlichiosisrodentstick-borne infection

More Related Videos

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research08:23

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

Published on: August 31, 2013

13.9K
Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR07:20

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

Published on: February 4, 2018

18.9K

Related Concept Videos

Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
1.4K
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
46
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
67
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
3.9K
Bacterial Phylum Chlamydiae01:29

Bacterial Phylum Chlamydiae

The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic...
781
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
759