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Updated: Apr 16, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

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Term histologic chorioamnionitis: a heterogeneous condition

Nathalie Conti1, Michela Torricelli1, Chiara Voltolini1

  • 1Obstetrics and Gynecology, Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|March 16, 2015
PubMed

A histologic response of histologic chorioamnionitis (HCA) is defined as an intrauterine inflammatory condition characterized by acute granulocyte infiltration into the fetal-maternal or the fetal tissues. Prevalence of HCA is inversely correlated with gestational age, occurring in 50% of preterm birth and in up to 20% of deliveries at term. Regardless of these standard definitions, understanding HCA is challenging as it reflects a heterogeneous condition. A histologic response of HCA from term placentas often does not correspond to a clinical presentation; in this context, the present review aims to analyze main characteristics of this condition, in particular focusing on mechanisms and birth outcomes.

Keywords:
DeliveryHistologic chorioamnionitisInfection/inflammationNeonatal outcomePlacentaTerm

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