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Updated: Apr 16, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Chemistry and bifunctional chelating agents for binding (177)Lu
Józef L Parus, Dariusz Pawlak, Renata Mikolajczak
1Laboratory of Nuclear Medicine, University of Ferrara, 44121 Ferrara, Italy. dta@unife.it.
Abstract:
A short overview of fundamental chemistry of lutetium and of structural characteristics of lutetium coordination complexes, as relevant for understanding the properties of lutetium-177 radiopharmaceuticals, is presented. This includes basic concepts on lutetium electronic structure, lanthanide contraction, coordination geometries, behavior in aqueous solution and thermodynamic stability. An illustration of the structure and binding properties of the most important chelating agents for the Lu(3+) ion in aqueous solution is also reported with specific focus on coordination complexes formed with linear and macrocyclic polydentate amino-carboxylate donor ligands.
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