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Release of [3H]dopamine from rat prefrontal cortex: modulation through presynaptic cholinergic heteroreceptors
1Laboratorio de Neuroquimica, Instituto Venezolano de Investigaciones Cientificas, Caracus, Venezuela.
Neuroscience Letters
|October 23, 1989
Abstract:
The release of tritiated dopamine ([3H]DA) from slices of the rat prefrontal cortex was studied using a superfusion technique. Release appeared to be voltage-dependent and also dependent on external Ca2+, suggesting the presence of a specific neurotransmitter release mechanism. gamma-Aminobutyric acid (GABA), aspartate, glutamate and serotonin had no effect on either basal DA release or K(+)-stimulated release. Carbachol, a cholinergic agonist, inhibited K(+)-stimulated DA release. The results demonstrate that cholinergic heteroreceptors on dopaminergic terminals of the prefrontal cortex modulate DA release.